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Photophysical and photochemical properties of potential porphyrin and chlorin photosensitizers for PDT

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DOI
10.1016/1011-1344(95)07241-1
Authors
Zenkevich, E.
Sagun, E.
Knyukshto, V.
Shulga, A.
Mironov, A.
Efremova, O.
Bonnett, R.
Pinda Songca, S.
Kassem, M.
Date
1996
Bibliographic entry
Photophysical and photochemical properties of potential porphyrin and chlorin photosensitizers for PDT / E. Zenkevich [et al.] // Journal of Photochemistry and Photobiology B: Biology. – 1996. – Vol. 33. – P. 171-180.
Abstract
Structural and optical properties as well as photophysical and photochemical parameters (excited S₁ and T₁ state lifetimes at 77 K and in the presence of O₂ in solution at 293 K; efficiencies of singlet oxygen, ¹Δg, generation) are presented for porphyrins and chlorins with potential for the PDT of cancer: chlorin p₆ and its trimethyl ester, chlorin e₆ and its Na₃ and K₃ salts, purpurin-18 and its monomethylester, 5,10,15,20-tetrakis(3-methoxyphenyl)porphyrin (TPPM), 5,10,15,20-tetrakis(2,4-difluoro-3-methoxyphenyl)porphyrin (TPPMF) and GaTTP in different solvents (ethanol, toluene, pyridine and buffer pH 7.4) at 77–300 K. It has been shown that for monomeric chlorin e₆, chlorin p₆ and its derivatives the photophysical parameters are similar, as follows: fluorescence lifetimes τₛ in the presence of oxygen are 3.2–4.5 ns at 293 K; fluorescence quantum yields φ₁ vary from 0.1 to 0.2 depending on the solvent; phosphorescence quantum yields φ₁ are of t order 10⁻⁵; T₁ state lifetimes τT = 1.5–2.0 ms at 77 K and 250–390 ns at 293 K in the presence of O₂. By use of the direct kinetic measurement of singlet oxygen emission at 1.27 μm on laserexcitation the quantum yields of ¹Δg generation by chlorins have been measured: φΔ = 0.35−0.68. In this case values of φ₁ and φΔ depend strongly on the solve probably because of the formation of aggregates. For TPPM, TPPMF and Ga-TPP the φΔ values measured are higher (0.87–0.98) and are explained by the higher intersystem crossing S₁ → T₁ quantum yields.
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https://rep.bntu.by/handle/data/30128
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